Effect of Vitamin D Replacement on Serum TSH in Women with Anti-TPO Positive Sub-clinical Hypothyroidism
Published: January 1, 2019 | DOI: https://doi.org/10.7860/JCDR/2019/38168.12426
Kiarash Aminian, Amir Bahrami, Mostafa Najafipour, Farzad Najafipour
1. Department of Endocrinology, Endocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
2. Department of Endocrinology, Endocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
3. Department of Internal Medicine, Young Researchers and Elite Club, Ardabil Branch, Islamic Azad University, Ardabil, Iran.
4. Department of Endocrinology, Endocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Correspondence
Dr. Farzad Najafipour,
Department of Endocrinology, Emam Reza Hospital, Endocrine Research Center,
Tabriz University of Medical Sciences, Tabriz, Iran.
E-mail: farzadnajafipour@gmail.com
Introduction: The coexistence of Sub-Clinical Hypothyroidism (SCH) and vitamin D deficiency is a common problem and may lead to various clinical disorders. Several genetic studies have shown an association between gene polymorphism of Vitamin D receptor and of 1a hydroxylase with autoimmune thyroid diseases.
Aim: To evaluate the effects of vitamin D3 replacement on Thyroid-Stimulating Hormone (TSH) and anti-TPO levels in women with SCH.
Materials and Methods: This clinical trial was performed on 58 Sub-Clinical Hypothyroidism vitamin D deficient women. Patients were treated with 50,000 unit/week vitamin D3 capsule for eight weeks and TSH, Free thyroxine (FT4) and anti-TPO levels were measured before and after drug administration, using an electrochemiluminescence system.
Results: The mean age of the population was 38.02±12.68 years. Vitamin D3 replacement caused serum 25(OH) D3 level correction in SCH patients (p<0.001). Additionally, a significant decrease in anti-TPO and TSH levels were also observed in anti-TPO positive patients (n=29) (p=0.002 and p=0.02, respectively). No significant differences in anti-TPO and TSH levels were seen in anti-TPO negative group (p=0.507 and p=0.447, respectively).
Conclusion: The study showed that vitamin D3 replacement may be considered as an effective therapy to reduce TSH and anti-TPO levels in vitamin D deficient SCH patients.
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